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In 2009, a double-blind randomised-controlled trial (RCT) found significant reductions in duration of outbreaks, the number of ulcers and the level of pain in those on B12, 1000 g per day sublingually (form not reported), regardless of B12 level

Since sepsis was usually caused by bacteria of enteric origin, the supposition was made that intestinal bacteria can translocate across the intestinal barrier under stress when the structural or functional integrity of the intestinal barrier is compromised

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Higgins JPT, Thomas J, Chandler J et al (2021) Cochrane handbook for systematic reviews of interventions version 6.2 Sterne JAC, Savovi J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomized trials

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Fu, C., Cheuk, C., Chiu, Y